Biologic Therapy for Asthma, Allergic Disease & Nasal Polyps

Biologic Therapy

Advanced Immune-Targeted Treatment in Leesburg, VA

For patients with moderate to severe asthma, chronic allergic disease, nasal polyps, or chronic hives that remain poorly controlled despite standard medications, biologic therapy may offer a highly effective treatment option.

At Allergy Asthma & Immunology Institute, Dr. Laura Ispas provides expert evaluation and personalized management of biologic therapies designed to target specific pathways in the immune system and reduce chronic inflammation.

What Are Biologic Medications?

Biologic therapies are advanced, targeted medications made from living proteins that work on specific immune pathways involved in allergic and inflammatory disease. Unlike traditional medications that broadly suppress symptoms, biologics are designed to address the underlying immune drivers of disease.

These treatments are used in carefully selected patients after thorough evaluation.

Conditions Treated with Biologic Therapy

Biologic medications may be used to treat:

  • Moderate to severe asthma
  • Allergic and eosinophilic asthma
  • Chronic rhinosinusitis with nasal polyps
  • Chronic hives (chronic spontaneous urticaria)
  • Severe atopic dermatitis (eczema)
  • Allergic disease not controlled with standard therapy

Biologic Medications We Prescribe

Dr. Ispas evaluates each patient individually to determine the most appropriate biologic therapy. Medications may include:

  • Nucala® (mepolizumab) – targets eosinophilic inflammation
  • Fasenra® (benralizumab) – reduces eosinophils involved in asthma
  • Tezspire® (tezepelumab) – broad pathway inhibition for severe asthma
  • Xolair® (omalizumab) – IgE-mediated allergic asthma and chronic hives
  • Dupixent® (dupilumab) – asthma, eczema, and nasal polyps


Other biologic therapies as clinically indicated such as Rhapsido, and many more awaiting soon FDA approval, 

What’s New with Biologic Treatments?

Biologic therapies for asthma, eczema, chronic hives, and nasal polyps are evolving rapidly, offering patients more targeted and effective options than ever before.

What’s new and important:

  • More precise targeting:Newer biologics focus on specific immune pathways (such as IL-5, IL-4/IL-13, IgE, and TSLP), allowing treatment to be better matched to each patient’s disease.
  • Broader eligibility:Some newer medications, such as Tezspire, can help patients even without classic allergic or eosinophilic markers.
  • Expanded approvals:Biologics like Dupixentand Xolair are now approved for multiple conditions, including asthma, eczema, chronic hives, and nasal polyps.
  • Less frequent dosing:Emerging therapies are being developed with longer dosing intervals, improving convenience and adherence.
  • Better quality of life:Many patients experience fewer flare-ups, reduced need for oral steroids, and improved daily functioning.

Not every patient needs a biologic, but for those with persistent or severe disease, these newer treatments can be life-changing when carefully selected and monitored.

Selection is based on symptoms, lab results, medical history, and prior treatment response.

Who Is a Candidate for Biologic Therapy?

You may be a candidate if you:

  • Have frequent asthma exacerbations
  • Require repeated courses of oral steroids
  • Have persistent symptoms despite daily controller medications
  • Have elevated eosinophils or allergic markers
  • Have chronic nasal polyps or severe eczema
  • Experience significant impact on quality of life


A comprehensive evaluation is required before starting therapy.

Evaluation Before Starting a Biologic

Before initiating biologic therapy, Dr. Ispas performs a detailed assessment that may include:

  • Review of prior treatments and response
  • Pulmonary function testing
  • Allergy testing
  • Blood tests (eosinophils, IgE, and other markers)
  • Review of imaging or specialist records when available


This ensures therapy is appropriate, effective, and safe.

How Are Biologic Medications Given?

Most biologic medications are administered by injection, either:

  • In the office under supervision, or
  • At home after appropriate training


Dosing frequency ranges from every 2 to 8 weeks, depending on the medication.

Insurance & Prior Authorization Support

Biologic medications typically require insurance prior authorization. Our office assists with:

  • Medical documentation
  • Prior authorization submissions
  • Coordination with specialty pharmacies
  • Ongoing monitoring and renewals


We work closely with patients to minimize delays and disruptions in treatment.

Benefits of Biologic Therapy

Many patients experience:

  • Fewer asthma attacks
  • Reduced need for oral steroids
  • Improved breathing and stamina
  • Better sleep
  • Improved quality of life


Response varies, and ongoing monitoring is essential.

Why Choose Allergy Asthma & Immunology Institute?

  • Allergy & Immunology specialist with over 25 years of clinical experience
  • Extensive experience managing biologic therapies
  • Individualized treatment selection
  • On-site testing and follow-up
  • Dedicated insurance support
  • Convenient Leesburg location serving Northern Virginia

TEZSPIRE® (tezepelumab)

Used for severe asthma. Helps reduce asthma attacks by blocking early inflammation signals.

Given as an injection every 4 weeks.

DUPIXENT® (dupilumab)

Used for asthma, eczema, nasal polyps, and chronic hives.

Given as an injection every 2 weeks (sometimes every 4 weeks).

XOLAIR® (omalizumab)

Used for allergic asthma, chronic hives, and nasal polyps.

Given as an injection every 2–4 weeks.

RHAPSODO® (remibrutinib)

Oral medication (not an injection) for chronic spontaneous urticaria (chronic hives).

Taken daily by mouth.

NUCALA® (mepolizumab)

Used for eosinophilic asthma.

Given as an injection every 4 weeks.

FASENRA® (benralizumab)

Used for severe eosinophilic asthma.

Given as an injection every 4 weeks initially, then every 8 weeks.

General Notes:

Biologics are not rescue medications.
Benefits may take weeks to months.
Regular follow-up is required.